A story set in the mid-1800's about a young doctor who has been trained in Western-style medicine and a young samurai who is trying to live up to the old traditions of his class and culture. The story is actually based upon real people - the doctor, Ryo-an, was Tezuka's great grandfather. The manga series was adapted to anime by Madhouse Studios and premiered in Japan on NTV on April 4, 2000.

• Koichi Yamadera
• Mitsuru Miyamoto
• Rica Matsumoto
• Fumiko Orikasa
• Ichiro Nagai
• Rokuro Naya
• Daisuke Gori
• Jurota Kosugi