Yoo Minwoo's first love was So Eunhye who gets into a car accident. Eunhye dies, leaving him behind. Shim Hyewon has suffered from a terrible heart disease ever since childhood. Miraculously, she finds that she will be obtaining a heart from a donor, Eunhye. Suffering from the pain of a heartache, Minwoo goes to Paris to study, the memories of Eunhye still hunts his heart. When he returns to Korea, fate takes a turn and brings Hyewon and Minwoo together. When the two first meet, Hyewon's heart (Eunhye's heart),oddly beats faster when she is around Minwoo. Park Jeongjae is Hyewon's boyfriend. Park Jeonga is Jeongjae's sister, she meets Minwoo in Italy and falls for him.

• Son Ye-jin
• Song Seung-heon
• Han Ji-hye
• Ryu Jin
• Ha Jae-yeong
• Shin Ae
• Cho Eun-sook
• Kim Hae-sook