The series begins in 1895 with Dr. Eleanor Bramwell, working in a London hospital. She is treated as an inferior by the male doctors, and her opinions are often ignored. After a disagreement with a senior doctor, Eleanor is dismissed. Her father, Dr. Robert Bramwell, recommends she join him in his private practice of rich, elderly clients. Fortunately, Eleanor receives a better offer. Lady Peters, a friend of the family, offers to fund a small hospital in a London slum, where Eleanor will treat the impoverished locals. Together, Eleanor and Lady Peters establish The Thrift, a free hospital with six beds. The Thrift is named for its location on Thrift Street.

• Jemma Redgrave
• Ruth Sheen
• David Calder
• Cliff Parisi
• Kevin McMonagle
• Jenny Agutter