Sirens focused on the work and lives of three rookie female Pittsburgh Police officers. Officer Sarah Berkezchuk is dealing with her failing marriage, Officer Lynn Stanton is a single mom, and second-generation cop Officer Molly Whelan has a bad attitude which starts to interfere with her job. Each rookie officer worked under a veteran cop, and each grows and becomes more focused as a result.

• A.J. Johnson
• Jayne Heitmeyer
• Liza Snyder
• Tim Thomerson
• Ellen David
• Christopher Judge
• Claude Genest
• J.H. Wyman